Vitamin C

Across 8 trials (576 women), oral magnesium may reduce leg cramp frequency versus placebo in some trials but results were inconsistent; oral calcium showed no clear benefit; vitamin B complex and vitamin C evidence was very low certainty. No intervention was supported by high-quality evidence.

Magnesium, B vitamins and zinc showed modest improvements in perceived stress and mood-related irritability; effects were inconsistent across trials.

Healthy members of the general population may benefit from augmented levels of vitamins/minerals via direct dietary supplementation. Specifically, supplementation led to improved ratings of stress, mental health and vigour and improved cognitive performance during intense mental processing.

Supplementation improved ratings of mental health and vigour, reduced subjective stress and mental fatigue, and improved performance on demanding multitasking.

Oral methionine loading raised homocysteine and acutely impaired flow-mediated endothelial function in healthy men.

Daily multivitamin users had 5.1% longer telomeres on average, and higher dietary vitamin C and E intakes were associated with longer telomeres.

Perifollicular haemorrhage and easy bruising resolved within weeks of vitamin C repletion in patients with dietary deficiency.

Studies in human volunteers have shown that vitamin C reduces serum urate (SU) levels. The aim of this study was to determine the effects of vitamin C on SU levels in patients with gout.

To examine the relationship of ascorbic acid, an antioxidant nutrient involved in cholesterol catabolism, to gallbladder disease, we analyzed data collected from a probability sample of US adults.

For vitamin C, there were 593 cataracts in the treated group and 581 in the placebo group (hazard ratio, 1.02; 95% confidence interval, 0.91-1.14).

Regular supplementation had a modest but consistent effect in reducing the duration of common cold symptoms... in five trials with participants under heavy short-term physical stress, the common cold risk was halved.

antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans

Among patients with IDA, oral iron supplements alone were equivalent to oral iron supplements plus vitamin C in improving hemoglobin recovery and iron absorption.

Total and supplemental vitamin C intake was significantly associated with higher risk for incident kidney stones in men, but not in women.

Regular vitamin C did not reduce cold incidence in the general population but shortened duration modestly

vitamin C (3637 dead/36,659 (9.9%) versus 2717 dead/29,283 (9.3%); 29 trials, RR 1.02, 95% CI 0.98 to 1.07)

Topical vitamin C may be a suitable alternative for melasma and photoaging, but more studies are needed.

Antioxidant vitamin supplementation prevents oxidative stress but does not enhance performance in young football athletes.

Antioxidant therapy in patients with OSA is associated with improved endothelial function, reduced oxidative stress, and improved sleep parameters.

Topical vitamin C application increased the thickness of the lower eyelid dermis and reduced the dark appearance caused by underlying vasculature.

Easy bruising and bleeding gums from vitamin C deficiency resolve rapidly with repletion.

Antioxidant vitamin formulations including vitamin C slowed progression of age-related macular degeneration.

The reduced endothelial-dependent vasodilation in untreated patients with OSA acutely improves by the free radical scavenger vitamin C.

Antioxidant supplements improved semen parameters, but evidence for live birth outcomes remained weak.

Flavonoid phlebotonics reduced symptoms of capillary fragility in chronic venous insufficiency.

There also was no significant effect of vitamin C on major cardiovascular events.

The multivariable hazard ratio (HR) for vitamin C supplement users compared with that for nonusers was 1.25 (95% CI: 1.05, 1.50).

Vitamins C and E and their combination are safe and effective treatments for reducing the severity of RLS in hemodialysis patients over the short-term.

These data do not support an association between a high daily intake of vitamin C or vitamin B6 and the risk of stone formation, even when consumed in large doses.

Overall, DOMS of the quadriceps was lower in S (1.1±0.3) than P (2.2±0.5) (P<0.05).

No clinical benefit could be demonstrated from active treatment. There are several possible explanations for this negative result, including the short duration of therapy. It is possible that antioxidant therapy, to be effective, needs to be given early in the SSc disease process, before the onset of irreversible tissue damage.

Supplementation for 8 weeks with a FoodState Vitamin C complex may improve haemostatic factors and fibrin network structures.

Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population.

Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system.

Vitamin C-enriched gelatin before loading doubled blood markers of collagen synthesis

Without discriminating the number of antibiotics used, there was no relationship with the eradication of the infection (OR: 1.98 [95%CI: 0.92-4.29] P=.08).

Se testing should be considered as soon as cardiac involvement is suspected. VitC testing should be considered in malnourished SSc patients, especially if skin involvement is extensive.

Short-term high-dose vitamin C and E supplementation attenuates muscle damage, hemolysis, and inflammatory responses to repeated taekwondo competitions.

Vitamin C accumulates in leukocytes and supports NK cell and phagocyte function

The vitamin C group had a 0.80-fold lower risk of getting a common cold than did the placebo group.

Serum progesterone rose significantly in the vitamin C group compared with untreated controls

Although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.

Geometric mean iron absorptions were 29.5% in normal-weight and 16.6% in overweight and obese women from meals with ascorbic acid.

Both vitamins and commercial supplements have low effectiveness in reducing DOMS, while polyphenols and other antioxidant supplements show moderate to good effectiveness in combating DOMS.

High intakes of beta-carotene or vitamin C combined with high magnesium compared with low intakes of both nutrients were significantly associated with lower (better) PTAs at high frequencies.

Experimentally induced ascorbic acid deficiency did not significantly alter bile acid metabolism, sterol balance, or biliary lipid composition in man.

There was no significant difference in mean iron absorption among the 3 dietary periods despite a range of mean daily intakes of dietary vitamin C of 51-247 mg/d.

Vitamin C is an essential cofactor for collagen hydroxylation and supplementation supports dermal collagen formation

Supplementation with increasing amounts of gelatin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the supplement was given.

Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage.

Nicotinamide reduced new non-melanoma skin cancers by 23% versus placebo