Outcome
    Moderate Evidence

    Vitamin C for Cold Prevention

    Cochrane meta-analysis: regular vitamin C (1+ g/day) fails to prevent colds generally, but in marathon runners, skiers, and soldiers in cold conditions it reduced incidence by ~50%. Duration is modestly shortened (~8% adults). Low-risk, low-cost, reasonable for active people.

    Overview

    Cochrane meta-analysis: regular vitamin C (1+ g/day) fails to prevent colds generally, but in marathon runners, skiers, and soldiers in cold conditions it reduced incidence by ~50%. Duration is modestly shortened (~8% adults). Low-risk, low-cost, reasonable for active people.

    Verdict

    Mixed evidence

    Vitamin C does not prevent colds in the general population but halves incidence in heavy exercisers and shortens colds ~8%.

    How It Works

    Antioxidant support of immune cell function; epithelial barrier maintenance; neutrophil chemotaxis support.

    Dosing & Protocol

    Typical dose

    Recommended dose
    1 g/day regularly during high-risk periods.
    Expected timeframe
    Across a season for prevention effect.

    Protocol

    form
    Ascorbic acid, or buffered ascorbate if stomach upset occurs; divided doses improve absorption above 200 mg
    duration
    Continuous regular use - starting it after symptoms begin has not shown consistent benefit
    co factor
    Take with food in divided doses. Evidence is mixed and unusually well characterised. The Cochrane review by Hemila and Chalker, covering 29 trials in 11,306 participants, found regular supplementation at 200 mg/day or more did not reduce the incidence of colds in the general population, but did shorten duration by about 8% in adults and 14% in children - roughly half a day off a typical cold. The clear exception is people under extreme physical stress: marathon runners, skiers and soldiers in subarctic conditions, where regular supplementation halved cold incidence.
    titration
    Up to 2,000 mg/day, which is the tolerable upper intake level for adults
    starting dose
    200 mg/day taken regularly, if using it at all; higher doses of 1-2 g/day have been used in trials

    Evidence

    Vitamin C for preventing and treating the common cold

    Score: 9/10
    2013
    systematic_review
    n=11306

    Hemila H, Chalker E

    Regular vitamin C did not reduce cold incidence in the general population but shortened duration modestly

    View source

    Safety

    Caveats

    Doses above 2 g/day cause loose stools. Starting vitamin C after symptoms begin does not help.

    Less likely to help if

    Most of the general population for prevention - only extreme-exertion groups saw reduced incidence.

    Medical Disclaimer

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.