Spermidine for Stem Cell Preservation
Spermidine has the most interesting regenerative mechanism and the least human proof.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 1-6mg/day or wheat germ sources
- Expected timeframe
- Unknown
Protocol
- form
- Wheat germ extract standardised for spermidine content; contains gluten unless certified gluten-free
- duration
- Not applicable - no human stem cell endpoint has been assessed
- co factor
- Evidence is insufficient. Autophagy is genuinely important for stem cell maintenance - it clears damaged mitochondria and preserves the quiescent state, and impaired autophagy accelerates stem cell exhaustion, one of the recognised hallmarks of ageing. Spermidine improves haematopoietic and muscle stem cell function in aged mice through autophagy induction, which is a real finding. No human study has assessed stem cell number, function or exhaustion after spermidine supplementation, because doing so requires bone marrow or tissue sampling and specialised flow cytometry, and no clinical measure of stem cell health exists.
- titration
- Not applicable
- starting dose
- Not established. Trials used 1.2-6 mg/day of spermidine from wheat germ extract
Evidence
What the studies say
No studies are yet linked to both Spermidine and Stem Cell Preservation.
Safety
Caveats
No human regenerative endpoints. Food sources cost less.
Less likely to help if
Medical Disclaimer
The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.
Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.