Fisetin for Stem Cell Preservation
Fisetin's senolytic effects could plausibly protect the stem cell niche, but human data does not exist.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- Experimental; no established protocol
- Expected timeframe
- Unknown
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. In aged mice, intermittent fisetin reduced senescent cell burden in bone marrow and adipose tissue and improved measures of haematopoietic and mesenchymal progenitor function - the rationale being that senescent cells secrete inflammatory factors that degrade the stem cell niche. No human study has examined stem cell number, function or niche quality after fisetin, and there is no practical clinical measure of it. This is an animal finding described as a human outcome.
- titration
- Not applicable
- starting dose
- Not applicable
Evidence
What the studies say
No studies are yet linked to both Fisetin and Stem Cell Preservation.
Safety
Caveats
Genuinely experimental. Online high-dose protocols are untested.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.