Fisetin for Lifespan Extension
Fisetin is the leading natural senolytic candidate — clearing zombie senescent cells in animals — with human trials currently underway.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- Trials use ~20 mg/kg/day for 2 consecutive days monthly — supplemental protocols remain experimental.
- Expected timeframe
- Not established
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. The headline finding is real but is a mouse finding: intermittent fisetin given to mice from 85 weeks of age extended median lifespan by around 10% and improved healthspan markers, an unusually robust result for a late-life intervention. There is no human lifespan data for fisetin and there cannot be for decades - lifespan trials in humans are impractical, so the field relies on surrogate markers that have not themselves been validated. Human trials to date use about 20 mg/kg/day for two days monthly and measure inflammatory and functional markers, not survival.
- titration
- Not applicable
- starting dose
- Not applicable
Evidence
What the studies say
No studies are yet linked to both Fisetin and Lifespan Extension.
Safety
Caveats
Human efficacy unproven; long-term safety unknown. Do not self-experiment with extreme doses. Best framed as a promising watch-this-space compound.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.