Resveratrol for Stem Cell Preservation
Resveratrol's regenerative claims rest on discredited mechanism and failed human translation.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- Not recommended for this purpose
- Expected timeframe
- n/a
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence indicates no demonstrated effect. Cell culture and rodent studies show resveratrol influences stem cell biology in various directions - promoting osteogenic differentiation of mesenchymal stem cells, reducing senescence in cultured stem cells, affecting haematopoietic and neural stem cell proliferation - though findings are dose-dependent and sometimes contradictory, with higher concentrations inhibiting proliferation. No human trial has measured circulating progenitor cells, tissue stem cell pools, or any stem cell endpoint after resveratrol supplementation. The concentrations used in cell culture are also typically 10-100 times higher than plasma levels achievable orally, given bioavailability under 1%.
- titration
- Not applicable
- starting dose
- Not applicable. No human trial has measured stem cell number, function or preservation after resveratrol
Evidence
What the studies say
Calorie restriction and resveratrol do not activate SIRT1 in healthy humans: a randomized controlled trial
Timmers S, de Ligt M, Phielix E +6 more
Resveratrol failed to improve insulin sensitivity, mitochondrial function or hepatic lipid content compared with placebo
Safety
Caveats
May interfere with training adaptations and anticoagulants.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.