Spermidine for Sirtuin Activation

Typical dose

Recommended dose

1-6mg/day, or wheat germ dietary sources

Expected timeframe

12+ weeks

Protocol

form

Wheat germ extract standardised for spermidine content; contains gluten unless certified gluten-free

duration

Not applicable - no human sirtuin endpoint has been assessed

co factor

Evidence is insufficient and the mechanistic link is indirect. Spermidine induces autophagy chiefly by inhibiting the acetyltransferase EP300, which shifts the cellular acetylation balance toward deacetylation - the same net direction as sirtuin activation, which is why the two are often conflated. Spermidine is not a sirtuin activator: it does not bind or stimulate SIRT1, and the autophagy it induces is largely sirtuin-independent, though some crosstalk has been reported in cell models. No human study has measured sirtuin expression or activity after spermidine, and no clinical assay for sirtuin activity exists.

titration

Not applicable

starting dose

Not established. Trials used 1.2-6 mg/day of spermidine from wheat germ extract

What the studies say

Less likely to help if