Fisetin for Sirtuin Activation
Fisetin is a senolytic candidate with essentially no completed human outcome data.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- Experimental; no established protocol
- Expected timeframe
- Unknown
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. Fisetin has been reported to activate SIRT1 in cell-based assays, alongside other flavonoids, which is how it entered the longevity supplement category. That literature carries a specific caution: the fluorescent assay used to identify most sirtuin activators, including resveratrol, produced artefacts that did not hold up with native substrates, and the whole class of dietary sirtuin activators has been substantially deflated as a result. No human study has measured sirtuin activity after fisetin, and there is no validated clinical assay for it.
- titration
- Not applicable
- starting dose
- Not applicable
Evidence
What the studies say
Fisetin: A Dietary Antioxidant for Health Promotion
Khan N, Syed DN, Ahmad N +1 more
Reviews preclinical evidence that fisetin acts as an antioxidant and anti-inflammatory flavonoid, modulating SIRT1, NF-kB, PI3K/Akt and mTOR signalling, with neuroprotective and anticancer activity in cell and animal models. Typical dietary intake is far below the doses used experimentally, and oral bioavailability is poor.
Safety
Caveats
Genuinely experimental. High-dose intermittent protocols circulating online are untested in humans.
Less likely to help if
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