Pterostilbene for Sirtuin Activation
Pterostilbene is better absorbed than resveratrol but inherits the same unproven premise.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 50-100mg/day
- Expected timeframe
- 8-12 weeks
Protocol
- form
- Pterostilbene
- duration
- Human trials ran 6-8 weeks
- co factor
- Evidence is insufficient. Pterostilbene, like resveratrol, is described as a sirtuin-activating compound, and cell and rodent studies show increased SIRT1 expression and activity, downstream AMPK activation, PGC-1alpha upregulation and effects on mitochondrial function. The wider sirtuin field has been contentious: the original resveratrol SIRT1 findings were challenged as an artefact of the fluorophore-tagged substrate used in the assay, and the resulting debate has not fully resolved. In humans, no trial has measured sirtuin activity, expression or any validated downstream marker after pterostilbene. Sirtuin activation is also a mechanism, not a health outcome.
- titration
- Not applicable - no human dose-response for sirtuin activation exists
- starting dose
- Not established for this outcome. Human trials used 50-250 mg/day and did not measure sirtuin activity
Evidence
What the studies say
No studies are yet linked to both Pterostilbene and Sirtuin Activation.
Safety
Caveats
Raised LDL reported at higher doses in one trial. Evidence base is thin.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.