Outcome
    Preliminary

    NMN for Insulin-Like Growth Factor

    NMN has no established effect on IGF-1 in humans.

    Overview

    NMN has no established effect on IGF-1 in humans.

    Verdict

    Insufficient evidence

    How It Works

    NMN raises NAD+ availability, a pathway distinct from growth hormone and IGF-1 regulation.

    Dosing & Protocol

    Typical dose

    Recommended dose
    Not established for this use
    Expected timeframe
    Not established

    Protocol

    form
    Not applicable; regulatory status contested
    duration
    Not applicable
    co factor
    Evidence is insufficient, and the goal is questionable. No human NMN trial has demonstrated a meaningful change in insulin-like growth factor 1. The trials at 250-1,000 mg/day over 6-12 weeks measured blood NAD+, insulin sensitivity, aerobic capacity and walking speed. More importantly, the direction of benefit is unclear: reduced IGF-1 signalling is one of the most reproducible longevity mechanisms across model organisms, with reduced growth hormone and IGF-1 signalling extending lifespan in worms, flies and mice, and people with Laron syndrome, who lack growth hormone receptor signalling, show strikingly low rates of cancer and diabetes. Higher IGF-1 in humans is associated with increased risk of prostate, breast and colorectal cancer. So raising IGF-1 sits awkwardly alongside the longevity framing NMN is usually sold with.
    titration
    Not applicable
    starting dose
    Not established

    Evidence

    What the studies say

    Human NMN trials have measured NAD+ metabolites, insulin sensitivity and walking capacity; IGF-1 is not a reported outcome with meaningful effects.

    No studies are yet linked to both NMN and Insulin-Like Growth Factor.

    Safety

    Caveats

    Long-term safety data remain limited.

    Less likely to help if

    Everyone: NMN has not been shown to alter IGF-1, and raising it may not be beneficial.

    Medical Disclaimer

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.