Insulin-Like Growth Factor
Balanced IGF-1 levels for tissue growth and repair.
TL;DR
IGF-1 is a balance, not a maximise-or-minimise target: too low impairs muscle and bone, too high is associated with cancer risk. Protein intake and training set the level in most people.
Why It Matters
IGF-1 mediates most growth hormone effects on muscle, bone and tissue repair. Low levels in older adults track frailty and poor recovery, while high-normal levels have been associated in cohort studies with increased prostate and breast cancer risk.
How to Measure
Biomarkers
Optimization Protocol
Consume adequate protein at 1.2-1.6 g/kg for most adults and train with resistance to support the anabolic response. Avoid deliberately pushing IGF-1 above the age-appropriate range. If levels are low, check for undernutrition, hypothyroidism or liver disease before considering endocrine causes.
Supporting Supplements
Whey Protein
Adequate protein, including whey, supports IGF-1 in older adults where intake is low.
Resveratrol
Resveratrol does not reliably alter IGF-1 in humans and may blunt training adaptation.
NMN
NMN has no established effect on IGF-1 in humans.
Supporting Research
Frequently Asked Questions
Typical Timeframe
8-12 weeks
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.