Effects of Hericium erinaceus (lion's mane) on cognitive function and nerve growth factor: a randomized double-blind trial
Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T
Published in Phytotherapy Research
Methodology
Randomized double-blind placebo-controlled trial of Hericium erinaceus in older adults with mild cognitive impairment, with repeated cognitive testing and follow-up after cessation.
Key Findings
Cognitive scores improved significantly during supplementation but returned toward baseline four weeks after stopping.
Conclusions
Lion's mane produces reversible cognitive gains consistent with a neurotrophic rather than structural effect.
Limitations
Small Japanese sample; nerve growth factor not measured directly in humans.
Supplements Studied
Cognitive scores improved significantly during supplementation but returned toward baseline after stopping
Outcomes Measured
Cognitive scores improved significantly during supplementation but returned toward baseline four weeks after stopping.
Cognitive scores improved significantly during supplementation but returned toward baseline four weeks after stopping.
Study Details
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