Lion's mane (Hericium erinaceus) and nerve growth factor-mediated neurite outgrowth: evidence review
Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN
Published in International Journal of Medicinal Mushrooms
Methodology
In vitro and animal studies of Hericium erinaceus extracts on NGF synthesis and neurite outgrowth, with reference to small human cognition trials.
Key Findings
Hericium extracts stimulated NGF-dependent neurite outgrowth in neuronal cells and improved cognitive scores in a small human trial.
Conclusions
Lion's mane plausibly promotes neurotrophic synaptic remodelling.
Limitations
Mostly preclinical; human evidence minimal.
Supplements Studied
Hericium extracts stimulated NGF-dependent neurite outgrowth in neuronal cells
Outcomes Measured
Hericium extracts stimulated NGF-dependent neurite outgrowth in neuronal cells and improved cognitive scores in a small human trial
Hericium extracts stimulated NGF-dependent neurite outgrowth in neuronal cells and improved cognitive scores in a small human trial.
Study Details
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