NMN for DNA Repair Enhancement
NMN raises NAD+ levels in humans, but DNA repair benefits remain unproven outside animal models.
Overview
Verdict
NMN raises NAD+ levels in humans, but DNA repair benefits remain unproven outside animal models.
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 250-500 mg daily
- Expected timeframe
- Not established
Protocol
- form
- Not applicable; regulatory status contested
- duration
- Not applicable
- co factor
- Evidence is insufficient. The mechanistic chain is real but untested in people: PARP1 and PARP2 consume NAD+ when repairing DNA strand breaks, sirtuins including SIRT1 and SIRT6 are NAD+-dependent and participate in the DNA damage response, and NAD+ decline with age has been proposed to limit repair capacity. Mouse studies show NMN or NR administration improves markers of DNA repair and reduces DNA damage accumulation. No human trial has measured DNA repair capacity, comet assay outcomes, gamma-H2AX foci or mutation burden following NMN supplementation - the human trials measured blood NAD+, insulin sensitivity, aerobic capacity and walking speed over 6-12 weeks. The claim is therefore entirely preclinical.
- titration
- Not applicable
- starting dose
- Not established
Evidence
What the studies say
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
Treatment with NR showed indications of upregulated gene pathways related to genomic integrity in the airways and reduced epigenetic aging.
Safety
Caveats
Expensive and experimental; the compelling data are in mice, not people.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.