Metabolic
    Strong Evidence

    Weight Loss Support

    Natural support for healthy weight management and fat loss.

    TL;DR

    Weight loss supplements produce 1-3kg at best, usually less than the difference made by protein intake and sleep. GLP-1 medications changed what effective actually means.

    Why It Matters

    Sustained weight loss requires an energy deficit maintained over time, and the hard part is adherence rather than mechanism. Supplement effects in meta-analyses cluster around 1-3kg, often within measurement noise and rarely maintained. Protein intake, resistance training and sleep are the levers that preserve lean mass and control appetite. GLP-1 receptor agonists now produce 15-20% body weight reduction, reframing what counts as a meaningful intervention and making most supplement claims look trivial by comparison. Weight loss products are also the category most frequently adulterated with undeclared pharmaceuticals such as sibutramine.

    How to Measure

    Weekly average weight plus waist measurement every 2 weeks over 8–12 weeks of consistent deficit.

    Biomarkers

    Body weight trend
    Waist circumference
    Body composition (DEXA or BIA)
    HbA1c and fasting insulin
    Blood pressure
    Lipid panel
    Liver enzymes

    Optimization Protocol

    1) Build a sustainable energy deficit around foods you will actually keep eating, since adherence beats optimality. 2) Eat 1.6-2.2g protein per kg body weight, which preserves lean mass and increases satiety. 3) Resistance train to protect muscle so that lost weight is mostly fat. 4) Sleep 7-9 hours; restriction raises ghrelin, lowers leptin and increases intake. 5) Increase daily walking and non-exercise activity, the most flexible component of expenditure. 6) Prioritise high-fibre, high-volume, minimally processed foods for satiety per calorie. 7) Track intake honestly for a period, since underreporting is near-universal. 8) Discuss GLP-1 medication with a clinician if BMI and comorbidity criteria are met, given far larger effect sizes than any supplement.

    Lifestyle Levers

    • Sustainable energy deficit
    • High protein intake
    • Resistance training
    • Sleep 7-9 hours
    • Increased daily activity
    • High-fibre whole foods
    • Honest intake tracking

    Supporting Supplements

    Supporting Research

    Frequently Asked Questions

    Typical Timeframe

    Sustainable loss of 0.5-1% body weight per week; maintenance is the longer project.

    Measurable Metric

    Body fat mass and waist circumference, alongside weekly average body weight

    Research Summary

    Studies22
    Supplements7
    Evidence
    Strong Evidence

    My Notes

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    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.