Epigenetic Age Reversal
Younger biological age markers through epigenetic modification.
TL;DR
Epigenetic clocks are research tools, not verified targets for intervention. Nothing sold as an anti-ageing supplement has been shown to slow real ageing; the levers with actual outcome data are exercise, sleep, not smoking, and body composition.
Why It Matters
DNA methylation clocks such as GrimAge and PhenoAge correlate with mortality and disease risk at population level, but individual test-retest variability is large enough to swamp most short-term changes. Treat a single result cautiously.
How to Measure
Biomarkers
Optimization Protocol
Focus on interventions with mortality data: aerobic and resistance training, seven to nine hours of sleep, no smoking, moderate alcohol at most, and a healthy body composition. If you test a methylation clock, retest with the same provider at least 12 months apart and ignore small swings. Treat NMN and resveratrol as experimental.
Supporting Supplements
Supporting Research
Frequently Asked Questions
Typical Timeframe
12 months minimum before retesting
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.