Examining nutrition strategies to influence DNA methylation and epigenetic clocks: a systematic review of clinical trials
Garcia-Garcia I, Grisotto G, Heini A
Published in Frontiers in Aging
Methodology
Systematic review of 21 intervention studies testing dietary patterns, specific nutrients and multivitamin or multimineral supplements on global DNA methylation and epigenetic clocks in adults
Key Findings
Findings were inconsistent: two of four dietary-pattern studies suggested lower epigenetic age acceleration, while nutrient-specific results were mixed
Conclusions
Evidence that nutrition can shift epigenetic clocks is preliminary and heterogeneous
Limitations
Small trials, varied methylation platforms and clock versions
Supplements Studied
We examined clinical studies in community-dwelling adults testing the effects of nutrition interventions on i) global DNA methylation and its proxies, and ii) epigenetic clocks.
Outcomes Measured
In four studies on the methylation effects of healthy dietary patterns, as defined by being rich in vegetables, fruits, whole-grains, and nuts and reduced in the intake of added sugars, saturated fat, and alcohol, two of them suggested that a healthy diet, is associated with lower epigenetic age acceleration
Study Details
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