Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock
Sae-Lee C, Corsi S, Barrow TM
Published in Molecular Nutrition & Food Research
Methodology
Analysis of methylation array data from intervention studies with folic acid plus vitamin B12 or monomeric and oligomeric flavanols in 44 and 13 participants
Key Findings
Epigenetic age estimated by the Horvath clock was reduced in women with the MTHFR 677CC genotype after folic acid plus vitamin B12
Conclusions
Methylation-age responses to supplementation depend on sex and genotype rather than being universal
Limitations
Secondary analysis of small datasets
Supplements Studied
After supplementation with folic acid + vitamin B12, epigenetic age, estimated by the Horvath "epigenetic clock" model, is reduced in women with the MTHFR 677CC genotype.
Epigenetic age estimated by the Horvath clock was reduced in women with the MTHFR 677CC genotype after folic acid plus vitamin B12
Outcomes Measured
After supplementation with folic acid + vitamin B12, epigenetic age, estimated by the Horvath "epigenetic clock" model, is reduced in women with the MTHFR 677CC genotype.
Study Details
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