rct
2024
High Quality
Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE 2 trial analysis
Hastings WJ, Ye Q, Wolf SE
Published in Aging Cell
Methodology
Analysis of the CALERIE 2 randomised controlled trial of two years of caloric restriction in healthy non-obese adults aged 21-50
Key Findings
Caloric restriction did not produce durable telomere-length preservation despite weight loss and metabolic improvement
Conclusions
Not every biological-aging biomarker responds to interventions that improve metabolic health
Limitations
Telomere length is a noisy aging biomarker; single cohort
Outcomes Measured
Caloric restriction (CR) modifies lifespan and aging biology in animal models.
Study Details
Year:2024
Duration:104 weeks
Quality Score:8/10
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