Outcome
    Limited

    L-Theanine for Sleep Maintenance

    L-theanine reduces pre-sleep arousal but has weak maintenance-specific evidence.

    Overview

    L-theanine reduces pre-sleep arousal but has weak maintenance-specific evidence.

    Verdict

    Insufficient evidence

    How It Works

    Increases alpha wave activity and modulates glutamate and GABA signalling.

    Dosing & Protocol

    Typical dose

    Recommended dose
    200-400mg before bed
    Expected timeframe
    2-4 weeks

    Protocol

    form
    Not applicable
    duration
    Not applicable
    co factor
    Evidence is insufficient for sleep maintenance specifically. Theanine has reasonable evidence for sleep quality and falling asleep - a four-week trial at 200 mg/day improved subjective sleep quality and reduced latency, and an actigraphy study in boys with ADHD at 400 mg/day found improved sleep efficiency. Sleep maintenance is a different problem. Theanine acts by reducing pre-sleep arousal, and it has a relatively short duration of action, so it is unlikely to influence awakenings in the second half of the night, and no trial has reported wake-after-sleep-onset as a primary outcome in adults. Nocturnal awakenings more often reflect sleep apnoea, alcohol, nocturia, pain, hot flushes or circadian factors than pre-sleep arousal.
    titration
    Not applicable
    starting dose
    Not applicable as an established treatment for staying asleep

    Evidence

    What the studies say

    Randomised trials show improved subjective sleep quality and reduced anxiety, with sleep architecture changes that are small and inconsistent.

    No studies are yet linked to both L-Theanine and Sleep Maintenance.

    Safety

    Caveats

    Not sedating. Better for hyperarousal than for physiological awakenings.

    Less likely to help if

    Everyone with maintenance insomnia: the effect has not been demonstrated, and the cause is usually elsewhere.

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.