Sleep
    Strong Evidence

    Sleep Maintenance

    Fewer nighttime awakenings and improved sleep continuity.

    TL;DR

    Staying asleep is a different problem from falling asleep. Melatonin barely helps maintenance; temperature, alcohol, late caffeine and sleep-restriction therapy matter far more.

    Why It Matters

    Sleep maintenance insomnia means frequent or prolonged night awakenings despite adequate opportunity. Common drivers include alcohol, which fragments the second half of the night as it metabolises, nocturia, pain, untreated sleep apnea, perimenopausal vasomotor symptoms, and conditioned hyperarousal. Cognitive behavioural therapy for insomnia is first-line and outperforms medication at long-term follow-up. Melatonin's trial evidence is mainly for sleep onset and circadian shifting, not maintenance, which is why it disappoints people who wake at 3am.

    How to Measure

    Biomarkers

    Sleep diary wake after sleep onset
    Insomnia Severity Index
    Actigraphy or wearable sleep staging
    Ferritin if restless legs suspected
    TSH
    Overnight oximetry if apnea suspected

    Optimization Protocol

    1) Keep the bedroom cool at 16-19C, since core temperature fall supports sleep continuity. 2) Cut alcohol, the most common and most reversible cause of second-half awakenings. 3) Follow a consistent wake time seven days a week, which stabilises circadian and homeostatic drive. 4) Use CBT-I techniques including stimulus control and sleep restriction, the first-line evidence-based treatment. 5) Stop caffeine 8-10 hours before bed given its long half-life. 6) Reduce evening fluid to limit nocturia, and get prostate symptoms assessed if relevant. 7) Block light fully and use a white noise source if the environment is disruptive. 8) Screen for sleep apnea, restless legs and perimenopause, which are frequently missed causes.

    Lifestyle Levers

    • Cool bedroom 16-19C
    • Alcohol elimination
    • Fixed wake time
    • CBT-I and sleep restriction
    • Caffeine cutoff 8-10h
    • Evening fluid management
    • Full darkness

    Supporting Supplements

    Supporting Research

    Frequently Asked Questions

    Typical Timeframe

    Alcohol removal helps within days. CBT-I produces durable change in 4-8 weeks.

    Research Summary

    Studies4
    Supplements6
    Evidence
    Strong Evidence

    My Notes

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    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.