rct
    2005

    Tryptophan and vitamin B6 status in relation to melatonin synthesis: a randomized controlled trial

    Hudson C, Hudson SP, Hecht T, MacKenzie J

    Published in Nutritional Neuroscience

    Methodology

    Randomized controlled trial of protein-source tryptophan supplementation measuring urinary 6-sulfatoxymelatonin and sleep outcomes.

    Key Findings

    Tryptophan supplementation increased overnight melatonin metabolite excretion and improved sleep continuity.

    Conclusions

    Tryptophan availability limits endogenous melatonin synthesis in some adults.

    Limitations

    Small sample; older study with limited blinding detail.

    Supplements Studied

    L-Tryptophan
    Amino Acid

    Tryptophan supplementation increased overnight melatonin metabolite excretion and improved sleep continuity.

    Melatonin
    Compound

    Tryptophan supplementation increased overnight melatonin metabolite excretion and improved sleep continuity.

    Outcomes Measured

    Tryptophan supplementation increased overnight melatonin metabolite excretion and improved sleep continuity

    Tryptophan supplementation increased overnight melatonin metabolite excretion and improved sleep continuity.

    Study Details

    Year:2005
    Sample Size:18
    Duration:3 weeks
    Quality Score:6/10

    This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.