Overview
Glycine has no established role in heat adaptation.
Verdict
Insufficient evidence
How It Works
Proposed thermoregulatory effects relate to glycine's influence on core temperature during sleep, which does not transfer to exercise in heat.
Dosing & Protocol
Typical dose
- Recommended dose
- Not established for this use
- Expected timeframe
- Not established
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. The idea comes from a real observation: 3 g glycine before bed causes peripheral vasodilation and lowers core body temperature by a few tenths of a degree, which is how it aids sleep onset. Extending that to heat tolerance during exercise or heat exposure is speculation - no trial has tested glycine for thermoregulation during heat stress, exercise capacity in the heat, or heat acclimatisation. The nocturnal temperature drop is small, occurs at rest, and vasodilation during heat stress is already maximal, so there is little reason to expect an additive effect. Heat acclimatisation through repeated exposure, hydration and cooling strategies are what work.
- titration
- Not applicable
- starting dose
- Not applicable
Evidence
What the studies say
No controlled trials assess glycine for heat tolerance or exertional heat strain.
No studies are yet linked to both Glycine and Heat Tolerance.
Safety
Caveats
Prioritise acclimation, fluid and sodium instead.
Less likely to help if
Everyone: no human heat tolerance data exist.
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