Outcome
    Limited
    Effectiveness 2/5

    L-Glutamine for Heartburn Relief

    Glutamine is a fuel for gut epithelial cells and is often suggested for mucosal healing, but no trial has tested it for heartburn.

    Overview

    Glutamine is a fuel for gut epithelial cells and is often suggested for mucosal healing, but no trial has tested it for heartburn.

    Verdict

    Insufficient evidence

    Mechanistically appealing for mucosal repair, essentially untested for reflux.

    How It Works

    Enterocytes and oesophageal epithelium use glutamine as a primary energy substrate for repair and tight junction maintenance after acid or inflammatory injury.

    Dosing & Protocol

    Typical dose

    Recommended dose
    Not established; no trial has tested glutamine for heartburn or reflux, and gut trials used 5-30 g/day for other endpoints
    Expected timeframe
    4-8 weeks

    Protocol

    dose
    5 g daily
    form
    L-glutamine powder
    timing
    Away from meals
    duration
    4-8 weeks

    Evidence

    What the studies say

    Glutamine has trial support in chemotherapy-induced mucositis and in reducing H. pylori-associated gastric damage in animal models. Human reflux endpoints have not been studied.

    No studies are yet linked to both L-Glutamine and Heartburn Relief.

    Safety

    Caveats

    Avoid in significant liver disease. Not a substitute for evaluating persistent reflux.

    Less likely to help if

    Everyone: reflux has effective treatments and glutamine has no evidence for it.

    Medical Disclaimer

    The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.

    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.