L-Glutamine for T-Cell Function Enhancement
Glutamine matters for lymphocytes under severe catabolic stress, not in healthy people.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 5-10g/day only in catabolic states
- Expected timeframe
- 2-4 weeks
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. Lymphocytes use glutamine at high rates during proliferation, and in vitro T-cell proliferation and cytokine production fall when glutamine is removed from culture medium - a genuine and well-characterised finding. Extending it to humans does not work: studies in athletes after prolonged exercise and in surgical patients have measured lymphocyte subsets and proliferative responses after glutamine supplementation with inconsistent results, and no trial has shown that any measured T-cell change produced a clinical benefit. In healthy people plasma glutamine is not limiting, so there is no deficit to correct.
- titration
- Not applicable
- starting dose
- Not applicable
Evidence
What the studies say
No studies are yet linked to both L-Glutamine and T-Cell Function Enhancement.
Safety
Caveats
No benefit in healthy, well-fed people. Avoid in liver and kidney disease.
Less likely to help if
Medical Disclaimer
The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.
Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.