Outcome
    Moderate Evidence

    Apigenin for NAD+ Restoration

    Apigenin inhibits the NAD-consuming enzyme CD38 in laboratory models, but human NAD data is absent.

    Overview

    Apigenin inhibits the NAD-consuming enzyme CD38 in laboratory models, but human NAD data is absent.

    Verdict

    Insufficient evidence

    How It Works

    CD38 is a major NAD glycohydrolase whose activity rises with age; inhibiting it preserves cellular NAD pools in preclinical models.

    Dosing & Protocol

    Typical dose

    Recommended dose
    No human dose established
    Expected timeframe
    Not established

    Protocol

    studied dose
    Mouse studies used the equivalent of high oral doses to inhibit CD38 and raise tissue NAD
    evidence note
    Verdict is insufficient - no human trial has measured NAD after apigenin
    what happened
    Tissue NAD rose and metabolic parameters improved in mice; oral bioavailability in humans is low and no human NAD measurement exists
    better first choices
    NMN or nicotinamide riboside have at least measured human NAD elevation, though clinical benefit remains unproven
    if you still trial it
    There is no dose to recommend and no accessible way to verify a change in your NAD levels

    Evidence

    What the studies say

    Mouse studies show raised tissue NAD and improved metabolic parameters with apigenin. No human trial has measured NAD levels after apigenin supplementation, and oral bioavailability is low.

    No studies are yet linked to both Apigenin and NAD+ Restoration.

    Safety

    Caveats

    Human bioavailability of oral apigenin is low, so mouse tissue concentrations are unlikely to be reached. Apigenin inhibits CYP enzymes and can raise levels of some medications. Avoid in pregnancy and alongside anticoagulants without medical advice.

    Less likely to help if

    Everyone, in the sense that no human response has been demonstrated.

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