Outcome
    Moderate Evidence

    Apigenin for Stress Resilience

    Any calming effect is likely small and comes from chamomile preparations rather than isolated apigenin.

    Overview

    Any calming effect is likely small and comes from chamomile preparations rather than isolated apigenin.

    Verdict

    Insufficient evidence

    How It Works

    GABA-A modulation dampens excitatory tone in limbic circuits involved in the stress response.

    Dosing & Protocol

    Typical dose

    Recommended dose
    No validated dose - apigenin alone is untested
    Expected timeframe
    Not established

    Protocol

    studied dose
    Chamomile extract 500-1500 mg/day in generalised anxiety disorder
    evidence note
    Verdict is insufficient - the trial evidence is for chamomile extract, not apigenin
    what happened
    Modest symptom reduction was seen, but the active constituents were never isolated and apigenin alone has not been tested
    better first choices
    Ashwagandha root extract has direct randomised stress and cortisol data
    if you still trial it
    Use a standardised chamomile extract, measure Perceived Stress Scale at baseline and week 4, and stop if unchanged

    Evidence

    What the studies say

    A randomised trial of chamomile extract in generalised anxiety disorder showed modest symptom reduction, but the active constituents were not isolated and apigenin alone is untested.

    Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial

    Score: 7/10
    2016
    rct
    n=93

    Mao JJ, Xie SX, Keefe JR +3 more

    Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial.

    View source

    Safety

    Caveats

    Asteraceae allergy risk. Additive sedation with anxiolytics and alcohol; additive bleeding risk with warfarin. CYP inhibition may raise levels of other medications. Avoid in pregnancy.

    Less likely to help if

    People with diagnosed anxiety disorders needing treatment, and those whose stress is situational or sleep-driven.

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.