Outcome
    Moderate Evidence

    Apigenin for Neuroprotection

    Neuroprotective effects are confined to cell and animal models.

    Overview

    Neuroprotective effects are confined to cell and animal models.

    Verdict

    Insufficient evidence

    How It Works

    Apigenin reduces neuroinflammatory cytokine signalling and oxidative stress and may promote neuronal differentiation in vitro.

    Dosing & Protocol

    Typical dose

    Recommended dose
    No human dose established
    Expected timeframe
    Not established

    Protocol

    studied dose
    Preclinical ischaemia and neurodegeneration models only, at doses not translatable to human intake
    evidence note
    Verdict is insufficient - no human neurological outcome data exists
    what happened
    Reduced neuronal loss in animal paradigms; nothing has been measured in people
    better first choices
    Omega-3 fatty acids and blood pressure control have real human neurological outcome data
    if you still trial it
    Dietary sources such as parsley, celery and chamomile tea are the sensible route, with no reason to expect a neurological effect

    Evidence

    What the studies say

    Preclinical models report reduced neuronal loss in ischaemia and neurodegeneration paradigms. No human neurological outcome data exists.

    No studies are yet linked to both Apigenin and Neuroprotection.

    Safety

    Caveats

    Extrapolating animal neuroprotection to humans has failed repeatedly for flavonoids. Apigenin inhibits CYP enzymes and may interact with medications. Low oral bioavailability. Avoid in pregnancy.

    Less likely to help if

    Everyone - no human response has been shown.

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.