Chronic Fatigue Relief
Reduced persistent exhaustion and improved daily energy levels.
TL;DR
Persistent fatigue is a symptom, not a diagnosis. Correcting iron deficiency and B12 deficiency produces the largest effects; CoQ10, NADH and Rhodiola show smaller, more variable benefits and should follow, not replace, a workup.
Why It Matters
Fatigue lasting more than six weeks warrants screening for anaemia, thyroid disease, sleep apnea, depression, and medication effects before any supplement is trialled. Mitochondrial support has an evidence base mainly in ME/CFS and fibromyalgia cohorts.
How to Measure
Biomarkers
Optimization Protocol
Test and correct ferritin below 50 ng/mL, B12 below 400 pg/mL, and vitamin D below 30 ng/mL. Then trial one agent at a time for 8 weeks: CoQ10 200-300 mg, NADH 10-20 mg, or Rhodiola 200-400 mg standardized. Pace activity to avoid post-exertional crashes.
Supporting Supplements
NADH
NADH shows promise for chronic fatigue in small trials, generally as an adjunct to CoQ10 rather than alone.
Rhodiola Rosea
Rhodiola reduces stress-related and burnout fatigue more consistently than it addresses pathological chronic fatigue.
CoQ10
CoQ10 shows moderate fatigue reduction in ME/CFS and fibromyalgia cohorts, often studied together with NADH.
Iron
Correcting iron deficiency is the single highest-yield intervention for unexplained fatigue in menstruating women.
Supporting Research
Frequently Asked Questions
Typical Timeframe
4-12 weeks depending on the underlying driver
Research Summary
My Notes
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This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.