NADH for Chronic Fatigue Relief
NADH shows promise for chronic fatigue in small trials, generally as an adjunct to CoQ10 rather than alone.
Overview
Verdict
NADH shows promise for chronic fatigue in small trials, generally as an adjunct to CoQ10 rather than alone.
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 10-20 mg daily on an empty stomach
- Expected timeframe
- 8-12 weeks
Protocol
- form
- Stabilised, enteric-coated NADH - unprotected NADH is degraded by stomach acid, so formulation matters more than usual here
- duration
- 8-12 weeks before judging
- co factor
- Take on an empty stomach in the morning; taking it later can interfere with sleep. Evidence is mixed and thin. Small randomised trials in myalgic encephalomyelitis/chronic fatigue syndrome report modest reductions in fatigue scores with 10-20 mg/day, and a trial combining NADH with coenzyme Q10 showed improvement in fatigue and sleep measures. But the studies are small, short, inconsistently blinded and heterogeneous in how fatigue was measured, and larger independent replication is absent. Mechanistically NADH is the reduced form of nicotinamide adenine dinucleotide and the direct electron donor to complex I of the mitochondrial electron transport chain, so a bioenergetic rationale exists - but oral bioavailability is poor and how much reaches mitochondria is unclear.
- titration
- Up to 20 mg/day. Trials in chronic fatigue syndrome have used 10-20 mg/day, sometimes with coenzyme Q10 at 200 mg/day
- starting dose
- 10 mg once daily on rising, at least 30 minutes before food
Evidence
What the studies say
No studies are yet linked to both NADH and Chronic Fatigue Relief.
Safety
Caveats
Take away from food; stimulating for some, so dose in the morning.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.