rct
    2025

    Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract

    Banihashemi ZS, Azizi-Fini I, Rajabi M, Maghami M

    Published in BMJ Supportive & Palliative Care

    Methodology

    Triple-blind randomised placebo-controlled trial in 64 nurses with post-COVID-19 chronic fatigue syndrome; 500 mg Astragalus root extract twice daily, outcomes measured at end of treatment and one month later.

    Key Findings

    Chronic fatigue prevalence fell to 13.8% at end of intervention and 17.2% one month later in the Astragalus group, while being in the control group increased the risk of persisting fatigue (OR = 12.36, p = 0.01).

    Conclusions

    Astragalus root extract reduced chronic fatigue in nurses with post-COVID-19 chronic fatigue syndrome.

    Limitations

    Single-centre, small sample, one occupational group, short follow-up, self-reported fatigue outcome.

    Supplements Studied

    Astragalus root extract has been shown to reduce chronic fatigue in nurses.

    Outcomes Measured

    Astragalus root extract has been shown to reduce chronic fatigue in nurses.

    Related Health Concerns

    Study Details

    Year:2025
    Sample Size:64
    Quality Score:6/10

    Disclosures

    Funding

    Not reported

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