Phosphatidylserine for Stress Hormone Regulation
Phosphatidylserine blunts exercise-induced cortisol spikes with limited broader data.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 300-800mg/day
- Expected timeframe
- 2-4 weeks
Protocol
- form
- Soy or sunflower-derived phosphatidylserine. Note the original Monteleone experiments used bovine cortex-derived material, which is no longer available following BSE concerns
- duration
- Trials ran 10 days to 3 weeks
- co factor
- Evidence is insufficient for this outcome as framed. What the trials show is narrow: phosphatidylserine blunted the acute ACTH and cortisol rise following an exercise or mental arithmetic stressor at 400-800 mg/day. No trial has shown it normalises a dysregulated HPA axis, alters diurnal cortisol rhythm, changes resting morning cortisol, or corrects any measurable endocrine abnormality. The doses used for this effect are also two to eight times those in the cognitive trials, and the studies are small, short and mostly from one research group. Stress hormone regulation implies restoring a disordered system, which has not been demonstrated at any dose.
- titration
- Not applicable - no dose has been shown to regulate baseline cortisol or HPA axis function
- starting dose
- Not established for ongoing stress hormone regulation. Trials used 400-800 mg/day in divided doses with meals for 10-15 days
Evidence
What the studies say
No studies are yet linked to both Phosphatidylserine and Stress Hormone Regulation.
Safety
Caveats
Older bovine-derived trial data may not apply to soy-derived products.
Less likely to help if
Medical Disclaimer
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.