Outcome
    Limited

    Nattokinase for Platelet Aggregation Reduction

    Nattokinase has plausible fibrinolytic activity but far too little human outcome data to recommend it.

    Overview

    Nattokinase has plausible fibrinolytic activity but far too little human outcome data to recommend it.

    Verdict

    Insufficient evidence

    How It Works

    A serine protease that degrades fibrin directly and may reduce plasma fibrinogen.

    Dosing & Protocol

    Typical dose

    Recommended dose
    2000 FU/day in studies
    Expected timeframe
    4-8 weeks

    Protocol

    form
    Not applicable
    duration
    Not applicable
    co factor
    Evidence is insufficient. Nattokinase is a fibrinolytic serine protease, and its documented action is on fibrin and on the fibrinolytic system through plasminogen activator inhibitor-1 - which is a different pathway from platelet aggregation. Platelets aggregate via ADP, thromboxane A2 and glycoprotein IIb/IIIa mechanisms, which is what aspirin and clopidogrel target. A few small studies at 2,000-4,000 FU/day have examined platelet or clotting parameters with inconsistent results, and no adequately powered randomised trial has demonstrated a reliable reduction in platelet aggregation in humans. So the fibrinolytic activity is real, but attributing an antiplatelet effect to nattokinase goes beyond the data - while the bleeding risk from combining it with real antiplatelet drugs is not theoretical.
    titration
    Not applicable
    starting dose
    Not established for this outcome

    Evidence

    What the studies say

    Small short-term trials report reductions in fibrinogen and blood pressure. No cardiovascular outcome trials exist, and product potency is poorly standardised.

    No studies are yet linked to both Nattokinase and Platelet Aggregation Reduction.

    Safety

    Caveats

    Do not combine with anticoagulants or antiplatelet drugs. Stop before surgery.

    Less likely to help if

    Everyone: no adequate trial shows an antiplatelet effect, while the bleeding risk is real.

    Medical Disclaimer

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.