Outcome
    Moderate Evidence
    Effectiveness 3/5

    Black Cohosh for Night Sweats Reduction

    Black cohosh reduces vasomotor symptom frequency in some trials and matches placebo in others.

    Overview

    Black cohosh reduces vasomotor symptom frequency in some trials and matches placebo in others.

    Verdict

    Mixed evidence

    Modest benefit for menopausal sweats; trial results conflict.

    How It Works

    Acts on serotonergic and opioid receptors involved in thermoregulation rather than as a phytoestrogen, which is why breast-tissue effects appear neutral.

    Dosing & Protocol

    Typical dose

    Recommended dose
    20-40 mg standardised extract twice daily
    Expected timeframe
    8-12 weeks

    Protocol

    form
    Standardised isopropanolic extract (2.5% triterpene glycosides), third-party tested
    step 1
    Confirm the sweats are menopausal - thyroid disease, infection, lymphoma, sleep apnoea and several medications also cause them
    timing
    With food, second dose in the early evening
    duration
    8-12 weeks to judge; maximum 6-12 months with review
    titration
    Hold at 40 mg/day; consider up to 80 mg/day only for partial response at 6 weeks
    measurement
    Nights disturbed by sweating per week, before and at week 12
    starting dose
    20 mg standardised isopropanolic extract twice daily with food

    Evidence

    What the studies say

    Trials of standardised isopropanolic extract report reductions in hot flush and night sweat frequency over 8-12 weeks, while several well-controlled US studies found no separation from placebo. Cochrane assessments conclude the evidence is insufficient to be confident.

    Black cohosh (Cimicifuga spp.) for menopausal symptoms

    Score: 9/10
    2012
    meta_analysis
    n=2027

    Leach MJ, Moore V

    There was no significant difference between black cohosh and placebo in the frequency of hot flushes or in menopausal symptom scores across the pooled trials.

    View source

    Safety

    Caveats

    Rare hepatotoxicity reported - stop with jaundice, dark urine or abdominal pain.

    Less likely to help if

    Women whose sweats are not menopausal, and those with severe symptoms better served by hormone therapy.

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.