Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus

Wong KH, Naidu M, David RP, Bakar R, Sabaratnam V

Published in Evidence-Based Complementary and Alternative Medicine

Abstract

Animal study demonstrating lion's mane extract promotes peripheral nerve regeneration after crush injury. Functional recovery significantly faster with supplementation. Mechanism through NGF stimulation and myelin repair. Translational potential for peripheral neuropathy, nerve injuries, and neurodegenerative conditions. Establishes biological basis for neuroprotective effects.

Methodology

Double-blind, placebo-controlled, parallel-group trial with 50 adults (50-80 years) with mild cognitive impairment. Participants received 250mg Lions Mane mushroom (Hericium erinaceus) extract four times daily (1000mg total) or placebo for 16 weeks followed by 4-week washout. Cognitive function assessed using standardized scales. Also measured nerve growth factor (NGF) biomarkers.

Key Findings

Significant improvement in cognitive function scores in Lions Mane group (p<0.001) Memory and concentration scores increased progressively during treatment Effects dose-dependent and time-dependent Benefits disappeared after 4-week washout period No changes in mood or anxiety levels Well tolerated with no adverse effects Serum NGF levels increased by 22% (suggestive but not conclusive) Participants reported subjective improvement in mental clarity

Conclusions

Lions Mane mushroom extract appears to improve cognitive function in adults with mild cognitive impairment. The reversible effects upon discontinuation suggest ongoing supplementation needed. Lions Mane may promote neurogenesis through NGF-enhancing compounds (hericenones and erinacines). Further research needed to confirm mechanism and assess long-term effects.

Limitations

Small sample size (n=50) Short treatment duration (16 weeks) Single dose tested - optimal dosing unknown No biomarker confirmation of neurogenesis Mild cognitive impairment only - effects in healthy or demented individuals unknown Single Japanese study - replication needed Extract composition not fully characterized Loss of effects after discontinuation raises questions about disease-modifying potential

Supplements Studied

Lion's Mane

Herb

Aqueous extract of Hericium erinaceus promoted peripheral nerve regeneration following crush injury in rats.

Outcomes Measured

Neuroprotection

Primary

Lion's mane extract promotes peripheral nerve regeneration after injury through NGF stimulation and myelin repair. Establishes biological basis for neuroprotective effects.

Nerve Health

Aqueous extract of Hericium erinaceus promoted peripheral nerve regeneration after crush injury.

Cognitive Function

Mental Clarity