Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study
Lugo JP, Saiyed ZM, Lane NE
Published in Nutrition Journal
Methodology
Multicenter, randomized, double-blind, placebo-controlled trial of 40 mg/day undenatured type II collagen versus glucosamine plus chondroitin or placebo for 180 days in knee osteoarthritis.
Key Findings
Undenatured type II collagen reduced total WOMAC score significantly more than placebo and than glucosamine plus chondroitin at 180 days.
Conclusions
Undenatured type II collagen improved knee osteoarthritis symptoms with good tolerability.
Limitations
Industry funded and sponsored product, moderate sample, single 180-day trial, no imaging endpoints.
Supplements Studied
Undenatured type II collagen reduced total WOMAC score significantly more than placebo and than glucosamine plus chondroitin at 180 days.
Undenatured type II collagen significantly improved total WOMAC score and knee function versus placebo
Undenatured type II collagen reduced total WOMAC score significantly more than placebo and than glucosamine plus chondroitin at 180 days.
Outcomes Measured
Undenatured type II collagen reduced total WOMAC score more than placebo over 180 days.
Related Health Concerns
Study Details
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