Nicotinamide riboside supplementation raises NAD+ and affects sirtuin signalling in humans: a randomized trial
Martens CR, Denman BA, Mazzo MR, Armstrong ML, Reisdorph N, McQueen MB, Chonchol M, Seals DR
Published in Nature Communications
Methodology
Randomized double-blind placebo-controlled crossover trial of 1000 mg/day nicotinamide riboside in healthy middle-aged and older adults measuring NAD+ metabolome and vascular function.
Key Findings
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated, with a suggestive reduction in systolic blood pressure but no significant change in most physiological endpoints.
Conclusions
NR raises the NAD+ substrate pool that sirtuins require, without proven downstream clinical benefit.
Limitations
Small crossover; short six-week exposure.
Supplements Studied
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated, with a suggestive reduction in systolic blood pressure but no significant change in most physiological endpoints.
Chronic supplementation with the NAD+ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD+ metabolism in healthy middle-aged and older adults.
Chronic supplementation with the NAD+ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD+ metabolism in healthy middle-aged and older adults.
Outcomes Measured
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated, with a suggestive reduction in systolic blood pressure but no significant change in most physiological endpoints
Nicotinamide riboside effectively doubled NAD+ levels and was well tolerated, with no significant change in most physiological endpoints
Chronic supplementation with the NAD+ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD+ metabolism in healthy middle-aged and older adults.
Study Details
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