Nicotinamide riboside and NAD+ repletion in stem cell and mitochondrial maintenance: evidence review
Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, Auwerx J
Published in Science
Methodology
Preclinical mechanistic studies of NAD+ repletion on mitochondrial unfolded protein response and muscle stem cell function in aged mice, reviewed alongside early human data.
Key Findings
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control.
Conclusions
NAD+ precursors preserve stem cell function in animals; human evidence pending.
Limitations
Animal data; no human stem-cell endpoints.
Supplements Studied
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control.
Outcomes Measured
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control
NAD+ repletion rejuvenated muscle stem cells and extended lifespan in aged mice via mitochondrial quality control
Study Details
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