Outcome
    Limited

    Saffron for Social Anxiety Reduction

    Saffron shows antidepressant and anxiolytic signals in small trials.

    Overview

    Saffron shows antidepressant and anxiolytic signals in small trials.

    Verdict

    Insufficient evidence

    How It Works

    Crocin and safranal modulate serotonergic and dopaminergic transmission.

    Dosing & Protocol

    Typical dose

    Recommended dose
    28-30mg standardised extract daily
    Expected timeframe
    6-8 weeks

    Protocol

    form
    Standardised Crocus sativus extract (2% safranal or 3.5% crocin)
    duration
    Not applicable
    co factor
    Evidence is insufficient. Saffron at 30 mg/day has randomised evidence for reducing general anxiety symptoms alongside depression, with a moderate effect size in meta-analysis. No trial has studied social anxiety disorder specifically, and it is a distinct condition with its own treatment response profile - characterised by fear of scrutiny and negative evaluation, typically beginning in adolescence, and responding particularly well to exposure-based cognitive behavioural therapy. Generalised anxiety scale improvements do not transfer automatically to social anxiety, which is often measured with the Liebowitz Social Anxiety Scale rather than the scales used in saffron trials.
    titration
    Not applicable
    starting dose
    Not established for this outcome. Anxiety trials used 30 mg/day of standardised extract

    Evidence

    What the studies say

    Meta-analyses of small trials report reductions in depression and anxiety scores comparable to low-dose SSRIs, but trials are short and largely from one region.

    No studies are yet linked to both Saffron and Social Anxiety Reduction.

    Safety

    Caveats

    Small, often unreplicated trials. Avoid high doses in pregnancy.

    Less likely to help if

    Everyone with social anxiety - untested, and effective specific treatment exists.

    Medical Disclaimer

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.