Compound

    Rutin

    Rutin

    TL;DR

    Rutin (and its semi-synthetic oxerutin relatives) has reasonable European trial support for venous insufficiency symptoms and leg edema, and much weaker evidence elsewhere.

    Ideal For

    • Chronic venous insufficiency with leg swelling
    • Hemorrhoid symptoms as an adjunct to fiber and topical care

    Avoid If

    • You are pregnant in the first trimester
    • You take anticoagulants without medical advice

    Frequently Asked Questions

    Overview

    Rutin's clinical record is dominated by hydroxyethylrutosides (oxerutins, Venoruton), a semi-synthetic derivative studied since the 1970s in chronic venous insufficiency. Placebo-controlled trials and a Cochrane review of phlebotonics conclude that rutosides reduce ankle edema, leg heaviness, cramps, and restless legs symptoms modestly, with effects comparable to other venoactive drugs such as diosmin. Evidence for hemorrhoid symptom relief in pregnancy and post-hemorrhoidectomy is present but of moderate quality. Beyond the venous system, rutin's reputation for capillary strengthening dates to mid-century "vitamin P" research that never developed into rigorous clinical support. Rutin is absorbed poorly and is largely hydrolyzed by gut bacteria to quercetin and smaller phenolics, meaning plain rutin supplements likely behave more like a low-dose quercetin source than like the pharmaceutical rutosides used in trials — a distinction most product labels ignore.

    How It Works

    • Reduces capillary permeability and microvascular leakage
    • Inhibits neutrophil activation in the venous wall
    • Antioxidant and metal-chelating flavonoid activity
    • Mild inhibition of platelet aggregation and aldose reductase

    Benefits & Outcomes

    No linked outcomes yet. Research is ongoing.

    Health Concerns Addressed

    Hemorrhoids

    condition
    Mixed evidence
    Limited
    Effectiveness 3/5

    A plausible adjunct to fiber and topical care, with trial support that is real but methodologically dated.

    Varicose Veins

    condition
    Likely effective
    Moderate Evidence
    Effectiveness 3/5

    Reasonable symptomatic support for venous leg symptoms — but buy the rutoside form actually used in trials, not generic rutin powder.

    Supporting Research
    11 studies

    Oral Administration of Forskolin and Rutin Contributes to Intraocular Pressure Control in Primary Open Angle Glaucoma Patients Under Maximum Tolerated Medical Therapy

    Score: 7/10
    2012
    rct

    Vetrugno M, Uva MG, Russo V +2 more

    Adding oral forskolin and rutin produced a further reduction in intraocular pressure compared with maximum tolerated medical therapy alone

    View source

    Phlebotonics for venous insufficiency

    Score: 8/10
    2020
    systematic_review
    n=10866

    Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D +5 more

    Phlebotonics are a class of drugs often used to treat CVI.

    View source

    A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency

    Score: 6/10
    2015
    systematic_review
    0

    Aziz Z, Tang WL, Chong NJ +1 more

    Hydroxyethylrutosides reduced oedema, pain, cramps and restless legs in chronic venous insufficiency.

    View source

    Phlebotonics for haemorrhoids

    Score: 9/10
    2012
    systematic_review

    Perera N, Liolitsa D, Iype S +2 more

    Numerous trials assessing the effect of phlebotonics in treating the symptoms and signs of haemorrhoidal disease suggest that there is a potential benefit.

    View source

    Phlebotonics for venous insufficiency

    Score: 8/10
    2016
    systematic_review
    0

    Martinez-Zapata MJ, Vernooij RW, Uriona Tuma SM +5 more

    Phlebotonics including rutosides produced a small reduction in oedema but no clear improvement in quality of life.

    View source

    Micronized purified flavonoid fraction containing hesperidin and diosmin for haemorrhoidal disease and chronic venous disease: systematic review and meta-analysis

    Score: 7/10
    2012
    systematic_review
    n=1514

    Perera N, Liolitsa D, Iype S +5 more

    Numerous trials assessing the effect of phlebotonics in treating the symptoms and signs of haemorrhoidal disease suggest that there is a potential benefit.

    View source

    United States Pharmacopeia comprehensive safety review of Styphnolobium japonicum flower and flower bud

    Score: 7/10
    2022
    systematic_review

    Madden E, McLachlan C, Oketch-Rabah H +1 more

    No serious adverse events or toxicity were reported in the clinical or experimental animal studies we reviewed.

    View source

    Efficacy of micronized purified flavonoid fraction (Daflon) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials

    Score: 8/10
    2018
    meta_analysis
    n=1692

    Kakkos SK, Nicolaides AN

    The main outcome measures were the individual and global symptoms, leg edema and redness, skin changes, QoL and evaluation of the overall effectiveness of the treatment by the physician.

    View source

    The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, BDNF, and serum inflammatory and oxidative stress factors in patients with type 2 diabetes mellitus: a double-blind, placebo-controlled trial

    Score: 6/10
    2023
    rct
    n=50

    Bazyar H, Moradi L, Zaman F +1 more

    In this trial (double-blind, placebo-controlled), 50 T2DM patients (supplement, n = 25 and placebo, n = 25) were randomized and supplemented with 500 mg rutin or placebo per day for 3-months.

    View source

    Interventions for varicose veins and leg oedema in pregnancy

    Score: 8/10
    2015
    systematic_review

    Smyth RM, Aflaifel N, Bamigboye AA

    Treatments of leg oedema comprise mostly symptom reduction rather than cure and use of pharmacological and non-pharmacological approaches.

    View source

    The reduction impact of monoglucosyl rutin on abdominal visceral fat: a randomized, placebo-controlled, double-blind, parallel-group study

    Score: 6/10
    2020
    rct
    n=66

    Hashizume Y, Tandia M

    AVF area in both the MR200 and MR400 groups was reduced at week 8, with changes from the baseline (week 0) significantly higher than the placebo group.

    View source

    Safety Information

    Potential Side Effects

    {"Mild GI upset, headache, flushing; rare rash"}

    Contraindications

    {"None established at typical doses"}

    Drug Interactions

    • Anticoagulants and antiplatelets (theoretical additive effect)
    • May affect absorption of some medications via transporter inhibition

    Pregnancy & Breastfeeding

    Pregnancy: insufficient_data

    Breastfeeding: insufficient_data

    Dosage Guidelines

    Dosage Used in Studies

    Consult healthcare provider

    Forms Compared

    Food & Timing

    With food to improve tolerability.

    Medical Disclaimer

    The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.

    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.