Outcome
    Limited

    Quercetin for Tumor Response Rate

    Quercetin is a preclinical curiosity with no human tumour response evidence.

    Overview

    Quercetin is a preclinical curiosity with no human tumour response evidence.

    Verdict

    Insufficient evidence

    How It Works

    Kinase inhibition and pro-apoptotic effects observed in cell lines.

    Dosing & Protocol

    Typical dose

    Recommended dose
    Discuss with oncology before use
    Expected timeframe
    n/a

    Protocol

    form
    Not applicable as an anticancer treatment
    duration
    Not applicable
    co factor
    Evidence is insufficient and there are grounds for caution. Quercetin shows antiproliferative, pro-apoptotic and anti-angiogenic activity across many cancer cell lines, and rodent xenograft studies show tumour growth inhibition - the preclinical literature is extensive. Human data do not follow: a phase I intravenous study in the 1990s reported some biological activity and dose-limiting renal toxicity, and no subsequent trial has demonstrated tumour response, progression-free survival or overall survival benefit with quercetin in any cancer. Meanwhile, quercetin inhibits CYP3A4 and P-glycoprotein, and its antioxidant activity has raised theoretical concerns about interference with radiotherapy and some chemotherapy agents.
    titration
    Not applicable
    starting dose
    Not established. Early-phase intravenous studies used 60-1,700 mg/m2, and oral supplement trials used 500-1,000 mg/day - none demonstrated tumour response

    Evidence

    What the studies say

    Laboratory work shows antiproliferative activity that has not been replicated in human trials. Potential interactions with chemotherapy metabolism are a concern.

    No studies are yet linked to both Quercetin and Tumor Response Rate.

    Safety

    Caveats

    May affect chemotherapy drug levels. Not a treatment.

    Less likely to help if

    Everyone - no tumour response evidence exists, and interaction with treatment is a real risk.

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    Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.