Quercetin for Inflammaging Reduction
Quercetin has senolytic interest but human anti-inflammatory data in ageing are preliminary.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 500-1000 mg daily of a bioavailable form
- Expected timeframe
- 8-12 weeks
Protocol
- form
- Bioavailability-enhanced quercetin. Note that senolytic research protocols used a different approach entirely - quercetin 1,000 mg with dasatinib 100 mg, a prescription chemotherapy drug, for 3 consecutive days repeated intermittently
- duration
- 8-12 weeks for inflammatory markers
- co factor
- Take with food containing fat. Evidence is mixed. Quercetin reduces inflammatory markers in some human trials - meta-analyses show modest reductions in CRP, particularly at doses of 500 mg/day or more, in trials of 8 weeks or longer, and in people with elevated baseline inflammation - while other trials show nothing. The senolytic angle is separate and much less established: small pilot studies in idiopathic pulmonary fibrosis and diabetic kidney disease used dasatinib plus quercetin and reported reduced senescent cell burden, but these were tiny, uncontrolled and used a prescription drug alongside.
- titration
- Up to 500 mg twice daily for continuous use; 1,000 mg/day for up to 12 weeks is the studied ceiling
- starting dose
- 500 mg once daily with a fat-containing meal for continuous use
Evidence
What the studies say
No studies are yet linked to both Quercetin and Inflammaging Reduction.
Safety
Caveats
Poor absorption unbuffered; interacts with several drug-metabolising enzymes.
Less likely to help if
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Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.