Magnesium for Sex Hormone Binding Globulin
Magnesium may slightly reduce testosterone binding, but the practical effect is small.
Overview
Verdict
How It Works
Dosing & Protocol
Typical dose
- Recommended dose
- 200-400mg/day elemental
- Expected timeframe
- 8-12 weeks
Protocol
- form
- Not applicable
- duration
- Not applicable
- co factor
- Evidence is insufficient. The claim traces to a single small study in which magnesium supplementation at 10 mg/kg/day for four weeks was associated with increased free and total testosterone in sedentary men and taekwondo athletes, combined with in vitro work suggesting magnesium may reduce the binding affinity of sex hormone binding globulin for testosterone, thereby increasing the free fraction. That in vitro finding has not been confirmed as a clinically relevant effect in humans, and no trial has measured SHBG concentration as a primary outcome of magnesium supplementation. SHBG is principally regulated by insulin, thyroid hormone, oestrogen, liver function and body fat - insulin resistance lowers it and thyrotoxicosis raises it - none of which magnesium addresses directly.
- titration
- Not applicable
- starting dose
- Not applicable as an established treatment
Evidence
What the studies say
No studies are yet linked to both Magnesium and Sex Hormone Binding Globulin.
Safety
Caveats
Loose stools with oxide forms. Effect size is modest at best.
Less likely to help if
Medical Disclaimer
The information provided on this website is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any supplement regimen.
Individual results may vary. The statements on this website have not been evaluated by the Food and Drug Administration. Products and information are not intended to diagnose, treat, cure, or prevent any disease.