A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein synthesis during inactivity and energy restriction in older persons
Oikawa SY, McGlory C, D'Souza LK, Morgan AK
Published in The American Journal of Clinical Nutrition
Methodology
Randomised controlled trial in 31 older adults (16 men, 15 women) comparing 30 g twice-daily whey protein versus collagen peptides across energy balance, energy restriction, step reduction and recovery phases modelling hospitalisation
Key Findings
Leg lean mass fell during inactivity and energy restriction; higher-quality whey protein better supported muscle protein synthesis and recovery than collagen peptides.
Conclusions
Protein quality, not just total intake, matters when rebuilding muscle after an illness-related period of inactivity.
Limitations
Small sample, healthy older volunteers simulating hospitalisation rather than actual patients.
Supplements Studied
Protein supplementation may represent a strategy to offset the loss of muscle during inactivity, and enhance recovery on resumption of activity.
whey protein (WP) or collagen peptides (CP): 30 g each, consumed 2 times/d
Outcomes Measured
In older persons, muscle loss is accelerated during physical inactivity and hypoenergetic states, both of which are features of hospitalization.
Study Details
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Disclosures
Funding
Non-commercial research support
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.