L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial
Sarris J, Byrne GJ, Cribb L, Oliver G, Murphy J, Macdonald P, Nazareth S, Karamacoska D, Galea S, Short A, Ee C, Birling Y, Menon R, Ng CH
Published in Journal of Psychiatric Research
Methodology
Ten-week double-blind, randomised, placebo-controlled adjunctive trial of L-theanine 450-900 mg/day in adults with generalised anxiety disorder on stable antidepressant therapy.
Key Findings
L-theanine did not outperform placebo on anxiety (HAMA) or insomnia severity, though it was well tolerated with no serious adverse events.
Conclusions
Adjunctive L-theanine did not reduce anxiety in generalised anxiety disorder.
Limitations
Modest sample size; adjunctive design in already-treated patients may mask effects.
Supplements Studied
L-theanine did not outperform placebo on anxiety or insomnia severity in generalised anxiety disorder.
Related Health Concerns
Study Details
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Disclosures
Funding
Australian academic funding with product supplied by manufacturer
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.