Schisandra chinensis extract improves liver enzymes and hepatic function: a systematic review of clinical studies
Kopustinskiene DM, Bernatoniene J
Published in Nutrients
Key Findings
Schisandra lignans consistently reduced serum ALT and AST across clinical and preclinical studies, with the synthetic analogue bicyclol licensed as a hepatoprotective drug.
Conclusions
Schisandra lignans have a coherent hepatoprotective mechanism with supportive but modest human data.
Limitations
Heterogeneous preparations, few high-quality randomised trials in Western populations.
Supplements Studied
Schisandra lignans consistently reduced serum ALT and AST, and the analogue bicyclol is licensed as a hepatoprotective drug.
Outcomes Measured
Schisandrin B activates Nrf2 and heat-shock protein pathways underlying the stress-protective effect.
Schisandra lignans consistently reduced serum ALT and AST, and the analogue bicyclol is licensed as a hepatoprotective drug.
Study Details
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