Effect of Salt Substitution on Cardiovascular Events and Death (SSaSS)
Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, Zhang J, Tian M, Huang L, Li Z, Yu Y, Zhao Y, Zhou B, Sun J, Liu Y, Yin X, Hao Z, Yu J, Li KC, Zhang X, Duan P, Wang F, Ma B, Shi W, Di Tanna GL, Stepien S, Shan S, Pearson SA, Li N, Yan LL, Labarthe D, Elliott P
Published in New England Journal of Medicine
Methodology
Open-label cluster-randomized trial of a potassium-enriched salt substitute versus regular salt in 600 Chinese villages over about 5 years
Key Findings
Stroke, major cardiovascular events and death were all significantly lower with the potassium-enriched salt substitute
Conclusions
Raising dietary potassium while lowering sodium reduces stroke and mortality
Limitations
Open-label design; high-risk rural population; excluded people with kidney disease
Supplements Studied
Stroke, major cardiovascular events and death were all significantly lower with the potassium-enriched salt substitute
Outcomes Measured
Stroke, major cardiovascular events and death were all significantly lower with the potassium-enriched salt substitute
Related Health Concerns
Study Details
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