Comparative efficacy of diverse therapeutic regimens for small intestinal bacterial overgrowth: a systematic network meta-analysis
Zhang Q, Li H, Chen C, Li M
Published in Therapeutic Advances in Gastroenterology
Methodology
Systematic review and Bayesian network meta-analysis of randomized controlled trials of SIBO treatments (antibiotics, probiotics, prokinetics) in adults, literature searched through December 2024, ranked by SUCRA.
Key Findings
Antibiotic regimens generally ranked highest for eradication, with probiotic and combination regimens showing benefit for symptoms; comparative certainty was limited by sparse networks.
Conclusions
Treatment ranking supports antibiotics first-line with adjunct roles for probiotics, but evidence quality is modest.
Limitations
Sparse network with few direct comparisons; heterogeneous diagnostic criteria.
Supplements Studied
The management of small intestinal bacterial overgrowth (SIBO) involves a range of therapeutic options such as antibiotics, probiotics, and prokinetic agents, yet their comparative clinical efficacy remains poorly characterized.
Related Health Concerns
Study Details
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Disclosures
Funding
Not reported
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