rct
    2019
    High Quality

    Effect of nicotinamide and lanthanum carbonate on serum phosphate in chronic kidney disease: the COMBINE randomized clinical trial

    Ix JH, Isakova T, Larive B

    Published in Journal of the American Society of Nephrology

    Key Findings

    Nicotinamide did not significantly lower serum phosphate or FGF23 in CKD and caused more gastrointestinal effects and thrombocytopenia.

    Conclusions

    Null with a safety signal at high therapeutic doses.

    Limitations

    Moderate sample, 12-month duration.

    Supplements Studied

    Nicotinamide did not lower serum phosphate in CKD and caused more gastrointestinal effects and thrombocytopenia.

    Phosphorus
    Mineral

    Nicotinamide did not significantly lower serum phosphate or FGF23 in CKD and caused more gastrointestinal effects and thrombocytopenia.

    Vitamin B3
    Vitamin

    Nicotinamide did not significantly lower serum phosphate or FGF23 in CKD and caused more gastrointestinal effects and thrombocytopenia.

    Related Health Concerns

    Chronic Kidney Disease

    Study Details

    Year:2019
    Sample Size:205
    Duration:52 weeks
    Quality Score:8/10

    Access Study

    View on DOIView on PubMedOriginal Source

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