Efficacy of micronized purified flavonoid fraction (Daflon) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials
Kakkos SK, Nicolaides AN
Published in International Angiology
Methodology
Systematic review and meta-analysis of 7 randomized double-blind placebo-controlled trials of micronized purified flavonoid fraction (MPFF) in chronic venous disease; GRADE used to rate certainty.
Key Findings
MPFF was more effective than placebo across individual venous symptoms including leg edema and redness, with improvements in quality of life and physician-assessed overall effectiveness.
Conclusions
MPFF improves leg swelling and other venous symptoms in chronic venous disease relative to placebo.
Limitations
Small number of included trials, most industry-sponsored, heterogeneity across symptom endpoints, and short treatment durations.
Supplements Studied
The main outcome measures were the individual and global symptoms, leg edema and redness, skin changes, QoL and evaluation of the overall effectiveness of the treatment by the physician.
Related Health Concerns
Study Details
Access Study
Disclosures
Funding
Not stated / industry-linked
This information is for educational purposes only. Always consult a healthcare professional before starting any supplement regimen.